TNFRSF10A anticorps (FITC)
-
- Antigène Voir toutes TNFRSF10A Anticorps
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp TNFRSF10A est conjugé à/à la FITC
-
Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody DR-4-02 recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
- Réactivité croisée (Details)
- Human
- Purification
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
- Clone
- DR-4-02
- Isotype
- IgG1
- Top Product
- Discover our top product TNFRSF10A Anticorps primaire
-
-
- Indications d'application
- Flow cytometry: Recommended dilution: 3-5 μg/mL.
- Commentaires
-
The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
-
- Reconstitution
- No reconstitution is necessary.
- Concentration
- 0.1 mg/mL
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
-
Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
-
-
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." dans: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).
: "
-
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." dans: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).
-
- Antigène
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Autre désignation
- CD261 / TRAIL-R1 (TNFRSF10A Produits)
- Synonymes
- anticorps APO2, anticorps CD261, anticorps DR4, anticorps TRAILR-1, anticorps TRAILR1, anticorps TNFRSF10A, anticorps TNF receptor superfamily member 10a, anticorps tumor necrosis factor receptor superfamily member 26, anticorps tumor necrosis factor receptor superfamily, member 10a, anticorps TNFRSF10A, anticorps LOC510798
- Sujet
- TNF receptor superfamily member 10a,TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).,DR4, APO2, TNFRSF10A, TRAILR1, TRAIL-R1
- ID gène
- 8797
- UniProt
- O00220
- Pathways
- Apoptose, Positive Regulation of Endopeptidase Activity
-