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STIM1 anticorps (C-Term)
STIM1
Reactivité: Humain, Rat, Souris
WB, IP, IHC (p), ICC
Hôte: Souris
Monoclonal
CDN3H4
unconjugated
Détail du produit anti-STIM1 anticorps
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Antigène
Voir toutes STIM1 Anticorps
STIM1
(Stromal Interaction Molecule 1 (STIM1))
Épitope
Tous les épitopes à travers STIM1 Anticorps.
C-Term
Reactivité
Toutes les réactivités sur STIM1 Anticorps
Humain, Rat, Souris
Hôte
Toutes les hôtes sur STIM1 Anticorps
Souris
Clonalité
Toutes les clonalités sur STIM1 Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers STIM1 Anticorps
Cet anticorp STIM1 est non-conjugé
Application
Tous les applications à travers STIM1 Anticorps.
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Specificité
The mouse monoclonal antibody CDN3H4 reacts with a cytoplasmic epitope of human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function.
Réactivité croisée (Details)
Human, Mouse, Rat
Purification
Purified by protein-A affinity chromatography.
Pureté
> 95 % (by SDS-PAGE)
Immunogène
Synthetized peptide (C-terminal cytoplasmic part of STIM1).
Clone
CDN3H4
Isotype
IgG1
Top Product
Discover our top product STIM1 Anticorps primaire
Alternatives
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anti-Stromal Interaction Molecule 1 (STIM1) (AA 56-69), (Extracellular), (N-Term) antibody
STIM1
Reactivité: Humain, Rat, Souris
WB, IHC, IP, IF, ICC, FACS, LCI
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
(cache)
Indications d'application
Immunocytochemistry: Methanol-aceton fixation, positive control: HeLa human cervix carcinoma cell line. Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL. Western blotting: Recommended dilution: 1 μg/mL, positive control: RBL rat basophilic leukemia cell line, both reducing and non-reducing conditions.
Restrictions
For Research Use only
Stockage
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Do not freeze.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Références pour anticorps anti-STIM1 (ABIN192394)
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Hájková, Bugajev, Dráberová, Vinopal, Dráberová, Janá?ek, Dráber, Dráber : "STIM1-directed reorganization of microtubules in activated mast cells. " dans: Journal of immunology (Baltimore, Md. : 1950) , Vol. 186 , Issue 2 , pp. 913-23 , (2011 ) (PubMed ).
Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume : "Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. " dans: American journal of physiology. Cell physiology , Vol. 299 , Issue 5 , pp. C1079-90 , (2010 ) (PubMed ).
Détails sur STIM1
(cache)
Antigène
STIM1
(Stromal Interaction Molecule 1 (STIM1))
Autre désignation
STIM1 (STIM1 Produits )
Synonymes
anticorps stim1, anticorps MGC76045, anticorps STIM1, anticorps si:dkey-24p1.5, anticorps MGC154748, anticorps si:ch211-112l17.2, anticorps Stim1, anticorps D11S4896E, anticorps GOK, anticorps TAM, anticorps SIM, anticorps stromal interaction molecule 1, anticorps stromal interaction molecule 1a, anticorps stromal interaction molecule 1 L homeolog, anticorps stromal interaction molecule 1b, anticorps STIM1, anticorps stim1, anticorps stim1a, anticorps stim1.L, anticorps stim1b, anticorps Stim1
Sujet
Stromal interaction molecule 1,STIM1 (stromal interacting molecule, also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.,GOK, TAM1, STRMK
ID gène
6786
UniProt
G0XQ39
Pathways
TCR Signaling , BCR Signaling
Vus récemment
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