CD24 anticorps (FITC)
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- Antigène Voir toutes CD24 Anticorps
- CD24 (CD24 Molecule (CD24))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD24 est conjugé à/à la FITC
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Application
- Flow Cytometry (FACS)
- Specificité
- The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
- Réactivité croisée (Details)
- Human
- Purification
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Glycoproteins purified from human NALM-1 cell line.
- Clone
- SN3
- Isotype
- IgG1
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Reconstitution
- No reconstitution is necessary.
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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Analysis of B-cell subpopulations in monoclonal gammopathies." dans: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).
: "Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice." dans: Gastroenterology, Vol. 143, Issue 5, pp. 1375-84.e1-5, (2012) (PubMed).
: "Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life." dans: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 23, Issue 1, pp. 245-50, (2011) (PubMed).
: "The human fetal omentum: a site of B cell generation." dans: The Journal of experimental medicine, Vol. 175, Issue 2, pp. 397-404, (1992) (PubMed).
: "Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 2, pp. 638-41, (1990) (PubMed).
: "Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3." dans: Hematological oncology, Vol. 4, Issue 4, pp. 251-9, (1987) (PubMed).
: "New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells." dans: Experimental hematology, Vol. 14, Issue 9, pp. 850-5, (1986) (PubMed).
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Analysis of B-cell subpopulations in monoclonal gammopathies." dans: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).
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- Antigène
- CD24 (CD24 Molecule (CD24))
- Autre désignation
- CD24 (CD24 Produits)
- Synonymes
- anticorps CD24A, anticorps Cd24a, anticorps CD24 molecule, anticorps CD24, anticorps Cd24
- Sujet
- CD24 Molecule,CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.,HSA, nectadorin, SCLC4
- ID gène
- 100133941
- UniProt
- P25063
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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