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UIMC1 anticorps (C-Term)

UIMC1 Reactivité: Humain WB, FACS Hôte: Lapin Polyclonal RB48354 unconjugated
N° du produit ABIN1944736
  • Antigène Voir toutes UIMC1 Anticorps
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Épitope
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 567-601, C-Term
    Reactivité
    • 31
    • 8
    • 5
    Humain
    Hôte
    • 28
    • 2
    • 1
    Lapin
    Clonalité
    • 31
    Polyclonal
    Conjugué
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UIMC1 est non-conjugé
    Application
    • 18
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.
    Clone
    RB48354
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Yan, Kim, Jetten: "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor." dans: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 32379-88, (2002) (PubMed).

  • Antigène
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Autre désignation
    UIMC1 (UIMC1 Produits)
    Synonymes
    anticorps UIMC1, anticorps RAP80, anticorps X2HRIP110, anticorps 9430016E08Rik, anticorps D330018D10Rik, anticorps D630032M02Rik, anticorps RIP110, anticorps Rxrip110, anticorps RGD1307009, anticorps ubiquitin interaction motif containing 1, anticorps UIMC1, anticorps Uimc1
    Sujet
    Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
    Poids moléculaire
    79727
    ID gène
    51720
    UniProt
    Q96RL1
    Pathways
    Réparation de l'ADN, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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