PAR1 anticorps

N° du produit ABIN1944818

Il existe 3+ publications pour ce produit. L’anticorps anti-PAR1 Polyclonal Lapin est utilisé pour la détection de PAR1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour PAR1 anticorps (ABIN1944818)

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PAR1 anticorps

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500- 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-PAR1 (ABIN1944818)

Zania, Gourni, Aplin, Nicosia, Flordellis, Maragoudakis, Tsopanoglou: "Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis." dans: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 2, pp. 378-89, (2009) (PubMed).

Kahn, Nakanishi-Matsui, Shapiro, Ishihara, Coughlin: "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin." dans: The Journal of clinical investigation, Vol. 103, Issue 6, pp. 879-87, (1999) (PubMed).

Shapiro, Trejo, Zeng, Coughlin: "Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization." dans: The Journal of biological chemistry, Vol. 271, Issue 51, pp. 32874-80, (1997) (PubMed).

Détails sur PAR1

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Autre désignation: Thrombin Receptor

Sujet: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Poids moléculaire: 47441 Da

ID gène: 2149

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus