CYP2A6
Reactivité: Humain
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:500-1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Stock
4 °C,-20 °C
Yamano, Tatsuno, Gonzalez: "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes." dans: Biochemistry, Vol. 29, Issue 5, pp. 1322-9, (1990) (PubMed).
Miles, Bickmore, Brook, McLaren, Meehan, Wolf: "Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity." dans: Nucleic acids research, Vol. 17, Issue 8, pp. 2907-17, (1989) (PubMed).
Yamano, Nagata, Yamazoe, Kato, Gelboin, Gonzalez: "cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)." dans: Nucleic acids research, Vol. 17, Issue 12, pp. 4888, (1989) (PubMed).
Antigène
CYP2A6
(Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
anticorps CPA6, anticorps CYP2A, anticorps CYP2A3, anticorps CYPIIA6, anticorps P450C2A, anticorps P450PB, anticorps cyp2a6, anticorps cytochrome P450 family 2 subfamily A member 6, anticorps cytochrome P450 2A6, anticorps cytochrome P450 family 2 subfamily A member 6 L homeolog, anticorps CYP2A6, anticorps cyp2a6.L
Sujet
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity.