CD74
Reactivité: Humain
WB, IHC
Hôte: Lapin
Monoclonal
unconjugated
Indications d'application
WB: 1:1000. FC: 1:25
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Kudo, Chao, Narni, Saunders: "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens." dans: Nucleic acids research, Vol. 13, Issue 24, pp. 8827-41, (1986) (PubMed).
OSullivan, Larhammar, Wilson, Peterson, Quaranta: "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 12, pp. 4484-8, (1986) (PubMed).
Claesson, Larhammar, Rask, Peterson: "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 24, pp. 7395-9, (1984) (PubMed).
Strubin, Mach, Long: "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity." dans: The EMBO journal, Vol. 3, Issue 4, pp. 869-72, (1984) (PubMed).
anticorps DHLAG, anticorps HLADG, anticorps II, anticorps Ia-GAMMA, anticorps CLIP, anticorps Ii, anticorps INVG34, anticorps Iclp-1, anticorps iclp1, anticorps wu:fb11f09, anticorps wu:fb12a01, anticorps wu:fb13d06, anticorps wu:fk94e07, anticorps Iclp-2, anticorps cd74, anticorps iclp2, anticorps zgc:123161, anticorps CD74 molecule, anticorps CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), anticorps CD74 molecule, major histocompatibility complex, class II invariant chain a, anticorps CD74 molecule, major histocompatibility complex, class II invariant chain b, anticorps CD74, anticorps Cd74, anticorps cd74a, anticorps cd74b
Sujet
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.