SHC3
Reactivité: Humain, Souris
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB - 1:1000
Restrictions
For Research Use only
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." dans: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).
Liu, Meakin: "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases." dans: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26046-56, (2002) (PubMed).
Nakamura, Sanokawa, Sasaki, Ayusawa, Oishi, Mori: "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway." dans: Oncogene, Vol. 13, Issue 6, pp. 1111-21, (1996) (PubMed).
Pelicci, Dente, De Giuseppe, Verducci-Galletti, Giuli, Mele, Vetriani, Giorgio, Pandolfi, Cesareni, Pelicci: "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions." dans: Oncogene, Vol. 13, Issue 3, pp. 633-41, (1996) (PubMed).
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. Synonyms: SHC-transforming protein 3, Neuronal Shc, N-Shc, Protein Rai, SHC-transforming protein C, Src homology 2 domain-containing-transforming protein C3, SH2 domain protein C3, SHC3, NSHC, SHCC