ARHGEF1 anticorps

N° du produit ABIN1944955

Détail du produit anti-ARHGEF1 anticorps

Antigène: ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGEF1 est non-conjugé

Application: Western Blotting (WB)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-ARHGEF1 (ABIN1944955)

Hart, Jiang, Kozasa, Roscoe, Singer, Gilman, Sternweis, Bollag: "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13." dans: Science (New York, N.Y.), Vol. 280, Issue 5372, pp. 2112-4, (1998) (PubMed).

Aasheim, Pedeutour, Smeland: "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues." dans: Oncogene, Vol. 14, Issue 14, pp. 1747-52, (1997) (PubMed).

Hart, Sharma, elMasry, Qiu, McCabe, Polakis, Bollag: "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase." dans: The Journal of biological chemistry, Vol. 271, Issue 41, pp. 25452-8, (1996) (PubMed).

Détails sur ARHGEF1

Antigène: ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))

Autre désignation: ARHGEF1 (ARHGEF1 Produits)

Synonymes: anticorps arhgef1, anticorps cb473, anticorps zgc:158261, anticorps ARHGEF1, anticorps GEF1, anticorps LBCL2, anticorps LSC, anticorps P115-RHOGEF, anticorps SUB1.5, anticorps Lbcl2, anticorps Lsc, anticorps Rho guanine nucleotide exchange factor (GEF) 1a, anticorps Rho guanine nucleotide exchange factor 1, anticorps Rho guanine nucleotide exchange factor (GEF) 1, anticorps arhgef1a, anticorps ARHGEF1, anticorps arhgef1, anticorps Arhgef1

Sujet: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.

Poids moléculaire: 102435 Da

ID gène: 9138

UniProt: Q92888

Pathways: Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling