C-JUN anticorps (pThr91)
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- Antigène Voir toutes C-JUN (JUN) Anticorps
- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
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Épitope
- pThr91
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp C-JUN est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. c-Jun (phospho-Thr91) antibody detects endogenous levels of c-Jun only when phosphorylated at threonine 91.
- Purification
- Immunoaffinity chromatography.
- Immunogène
- The antiserum was produced against synthesized phosphopeptide derived from human c- Jun around the phosphorylation site of threonine 91 (T-T-TP-P-T).
- Top Product
- Discover our top product JUN Anticorps primaire
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- Indications d'application
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Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at -20 °C.
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- Antigène
- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
- Autre désignation
- AP-1 / C-Jun (JUN Produits)
- Synonymes
- anticorps AP-1, anticorps AP1, anticorps c-Jun, anticorps fj36h07, anticorps wu:fj36h07, anticorps zgc:65863, anticorps Junc, anticorps c-jun, anticorps CG2275, anticorps D-Jun, anticorps D-jun, anticorps D-jun/Jra, anticorps DJUN, anticorps DJun, anticorps Djun, anticorps Dmel\\CG2275, anticorps JRA, anticorps JUN, anticorps Jun, anticorps V, anticorps cJun, anticorps d-JRA, anticorps d-Jun, anticorps d-jun, anticorps dAP-1, anticorps dJRA, anticorps dJUN, anticorps dJra, anticorps dJun, anticorps djun, anticorps dm-Jun, anticorps jra, anticorps jun, anticorps l(2)46Ef, anticorps l(2)IA109, anticorps l(2R)IA109, anticorps Jun proto-oncogene, AP-1 transcription factor subunit, anticorps jun proto-oncogene S homeolog, anticorps jun proto-oncogene, anticorps Jun-related antigen, anticorps jun proto-oncogene L homeolog, anticorps JUN, anticorps Jun, anticorps jun.S, anticorps jun, anticorps Jra, anticorps jun.L
- Sujet
- The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.Synonyms: Activator protein 1, Proto-oncogene c-jun, Transcription factor AP1, V-jun avian sarcoma virus 17 oncogene homolog, p39
- ID gène
- 3725
- NCBI Accession
- NP_002219
- UniProt
- P05412
- Pathways
- Signalisation MAPK, Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins
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