BCR anticorps (pTyr177)
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- Antigène Voir toutes BCR Anticorps
- BCR (Breakpoint Cluster Region (BCR))
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Épitope
- pTyr177
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BCR est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of Bcr only when phosphorylated at Tyrosine 177.
- Purification
- Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogène
- The antiserum was produced against synthesized phosphopeptide derived from Human Bcr around the phosphorylation site of Tyrosine 177 (P-F-Yp-V-N).
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- Discover our top product BCR Anticorps primaire
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- Indications d'application
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Suitable for use in Western blot (1/500-1/1000) and Immunohistochemistry onParaffin-Embedded Sections (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at -20 °C.
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- Antigène
- BCR (Breakpoint Cluster Region (BCR))
- Autre désignation
- BCR (BCR Produits)
- Synonymes
- anticorps si:dkey-83d9.7, anticorps zK83D9.7, anticorps BCR, anticorps ALL, anticorps BCR1, anticorps CML, anticorps D22S11, anticorps D22S662, anticorps PHL, anticorps 5133400C09Rik, anticorps AI561783, anticorps AI853148, anticorps mKIAA3017, anticorps breakpoint cluster region, anticorps BCR, RhoGEF and GTPase activating protein, anticorps bcr, anticorps BCR, anticorps Bcr
- Sujet
- The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.Synonyms: BCR1, Breakpoint cluster region protein, D22S11, NY-REN-26, Renal carcinoma antigen NY-REN-26
- ID gène
- 613
- NCBI Accession
- NP_004318
- UniProt
- P11274
- Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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