IL3RA anticorps (Biotin)

N° du produit ABIN1981851

Détail du produit anti-IL3RA anticorps (Biotin)

Antigène: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL3RA est conjugé à/à la Biotin

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The mouse monoclonal antibody 6H6 recognizes an extracellular epitope of CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogène: IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells

Clone: 6H6

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-12 μg/mL.

Commentaires:

The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-IL3RA (Biotin) (ABIN1981851)

Martín-Gayo, Sierra-Filardi, Corbí, Toribio: "Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development." dans: Blood, Vol. 115, Issue 26, pp. 5366-75, (2010) (PubMed).

Herling, Teitell, Shen, Medeiros, Jones: "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin." dans: Blood, Vol. 101, Issue 12, pp. 5007-9, (2003) (PubMed).

Sun, Woodcock, Rapoport, Stomski, Korpelainen, Bagley, Goodall, Smith, Gamble, Vadas, Lopez: "Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist." dans: Blood, Vol. 87, Issue 1, pp. 83-92, (1996) (PubMed).

Détails sur IL3RA

Antigène: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Autre désignation: CD123 (IL3RA Produits)

Synonymes: anticorps CD123, anticorps IL3R, anticorps IL3RAY, anticorps IL3RX, anticorps IL3RY, anticorps hIL-3Ra, anticorps CDw123, anticorps SUT-1, anticorps Cyrl, anticorps interleukin 3 receptor subunit alpha, anticorps interleukin 3 receptor, alpha chain, anticorps IL3RA, anticorps Il3ra

Sujet: Interleukin 3 receptor subunit alpha,CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.,IL3RA, MGC34174, hIL-3Ra

ID gène: 3563

UniProt: P26951

Pathways: Signalistation JAK/STAT