CD1b anticorps

N° du produit ABIN1981866

Détail du produit anti-CD1b anticorps

Antigène: CD1b (CD1B)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD1b est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The mouse monoclonal antibody SN13 (also known as K5-1B8) recognizes an extracellular epitope of CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: A cell membrane antigen preparation that was isolated from normal human thymocytes

Clone: SN13

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD1b (ABIN1981866)

Giuliani, Prete, Graziani, Aquino, Balduzzi, Sugita, Brenner, Iona, Fattorini, Orefici, Porcelli, Bonmassar: "Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells." dans: Infection and immunity, Vol. 69, Issue 12, pp. 7461-70, (2001) (PubMed).

Hayes, Knight: "Group 1 CD1 genes in rabbit." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 403-10, (2001) (PubMed).

Tentori, Graziani, Porcelli, Sugita, Brenner, Madaio, Bonmassar, Giuliani, Aquino: "Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes." dans: Antimicrobial agents and chemotherapy, Vol. 42, Issue 3, pp. 550-4, (1998) (PubMed).

Détails sur CD1b

Antigène: CD1b (CD1B)

Autre désignation: CD1b (CD1B Produits)

Sujet: CD1b molecule,CD1b (also known as R1) together with CD1a and c, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. Besides non-peptide glycolipid antigen presentation to CD1-restricted T cells, CD1b has been implicated in thymocyte development.,R1

ID gène: 910

UniProt: P29016