Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CD1c anticorps

CD1C Reactivité: Humain FACS, IHC, IP Hôte: Souris Monoclonal L161 unconjugated
N° du produit ABIN1981870
  • Antigène Voir toutes CD1c (CD1C) Anticorps
    CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
    Reactivité
    • 56
    • 3
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 28
    • 27
    • 1
    Souris
    Clonalité
    • 29
    • 27
    Monoclonal
    Conjugué
    • 24
    • 8
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD1c est non-conjugé
    Application
    • 31
    • 28
    • 15
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Specificité
    The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    human thymocytes
    Clone
    L161
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD1C Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze. Do not use after expiration date stamped on vial label.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Scharf, Li, Hawk, Garzón, Zhang, Fox, Kazen, Shah, Haddadian, Gumperz, Saghatelian, Faraldo-Gómez, Meredith, Piccirilli, Adams: "The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation." dans: Immunity, Vol. 33, Issue 6, pp. 853-62, (2010) (PubMed).

    del C Salamone, Mendiguren, Salamone, Fainboim: "Membrane trafficking of CD1c on activated T cells." dans: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 567-77, (2001) (PubMed).

    Briken, Jackman, Watts, Rogers, Porcelli: "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens." dans: The Journal of experimental medicine, Vol. 192, Issue 2, pp. 281-8, (2000) (PubMed).

    Todate, Chida, Suda, Imokawa, Sato, Ide, Tsuchiya, Inui, Nakamura, Asada, Hayakawa, Nakamura: "Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis." dans: American journal of respiratory and critical care medicine, Vol. 162, Issue 1, pp. 148-53, (2000) (PubMed).

  • Antigène
    CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
    Autre désignation
    CD1c (CD1C Produits)
    Synonymes
    anticorps BDCA1, anticorps CD1, anticorps CD1A, anticorps R7, anticorps CD1c molecule, anticorps CD1C
    Sujet
    CD1c molecule,CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.,R7, BDCA1
    ID gène
    911
    UniProt
    P29017
Vous êtes ici:
Support technique