CD42a anticorps

N° du produit ABIN1981875

Détail du produit anti-CD42a anticorps

Antigène: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Reactivité: Humain, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD42a est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.

Réactivité croisée (Details): Human, Canine (Dog)

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human acute lymphoblastic leukemia cells

Clone: GR-P

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD42a (ABIN1981875)

Din, Aftab, Jubb, Carnegy, Lyall, Sarma, Newby, Flapan: "Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans." dans: European journal of clinical nutrition, Vol. 65, Issue 2, pp. 234-9, (2011) (PubMed).

Harding, Din, Sarma, Josephs, Fox, Newby: "Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin." dans: Heart (British Cardiac Society), Vol. 92, Issue 11, pp. 1635-8, (2006) (PubMed).

Brown, Clarke, Magowan, Sanderson, Savill: "Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5987-96, (2000) (PubMed).

Détails sur CD42a

Antigène: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Autre désignation: CD42a (GP9 Produits)

Synonymes: anticorps cd42a, anticorps gpix, anticorps GP9, anticorps GPIX, anticorps Cd42, anticorps CD42a, anticorps glycoprotein IX platelet, anticorps glycoprotein IX platelet L homeolog, anticorps glycoprotein IX (platelet), anticorps glycoprotein 9 (platelet), anticorps GP9, anticorps gp9.L, anticorps Gp9

Sujet: Glycoprotein IX platelet,CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.,GPIX, GP9

ID gène: 2815

UniProt: P14770