LRRC32 anticorps

N° du produit ABIN1981876

Détail du produit anti-LRRC32 anticorps

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRRC32 est non-conjugé

Application: Western Blotting (WB)

Specificité: The mouse monoclonal antibody GARP5 recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Purified human sGARP protein

Clone: GARP5

Isotype: IgG1

Information d'application

Indications d'application: Western blotting: Recommended dilution: 1-2 μg/mL, positive control: human thrombocytes, reducing conditions

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LRRC32 (ABIN1981876)

Wang, Zhu, Dong, Shi, Lu, Springer: "GARP regulates the bioavailability and activation of TGF?." dans: Molecular biology of the cell, Vol. 23, Issue 6, pp. 1129-39, (2012) (PubMed).

Détails sur LRRC32

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Autre désignation: GARP / LRRC32 (LRRC32 Produits)

Synonymes: anticorps D11S833E, anticorps GARP, anticorps AI426318, anticorps D11S833Eh, anticorps D7H11S833E, anticorps EG434215, anticorps Garp, anticorps leucine rich repeat containing 32, anticorps LRRC32, anticorps Lrrc32

Sujet: Leucine rich repeat containing 32,GARP (glycoprotein A repetitions predominant protein), also known as garpin or LRRC32 (leucin-rich repeat containing protein 32) is an approximately 80 kDa transmembrane glycoprotein detected on the surface of megakaryocytes, platelets, and activated Treg cells. It binds to the latency-associated peptide (LAP) domain of pro-TGF beta and regulates its storage and activation. The expression of GARP on Treg cells seems to be necessary for their suppressive functions.,GARP, D11S833E

ID gène: 2615

UniProt: Q14392

Pathways: Activated T Cell Proliferation