CD42a anticorps (FITC)

N° du produit ABIN1981888

Détail du produit anti-CD42a anticorps (FITC)

Antigène: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Reactivité: Humain, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD42a est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.

Réactivité croisée (Details): Human, Canine (Dog)

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Human acute lymphoblastic leukemia cells

Clone: GR-P

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD42a (FITC) (ABIN1981888)

Din, Aftab, Jubb, Carnegy, Lyall, Sarma, Newby, Flapan: "Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans." dans: European journal of clinical nutrition, Vol. 65, Issue 2, pp. 234-9, (2011) (PubMed).

Harding, Din, Sarma, Josephs, Fox, Newby: "Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin." dans: Heart (British Cardiac Society), Vol. 92, Issue 11, pp. 1635-8, (2006) (PubMed).

Brown, Clarke, Magowan, Sanderson, Savill: "Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5987-96, (2000) (PubMed).

Détails sur CD42a

Antigène: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Autre désignation: CD42a (GP9 Produits)

Synonymes: anticorps cd42a, anticorps gpix, anticorps GP9, anticorps GPIX, anticorps Cd42, anticorps CD42a, anticorps glycoprotein IX platelet, anticorps glycoprotein IX platelet L homeolog, anticorps glycoprotein IX (platelet), anticorps glycoprotein 9 (platelet), anticorps GP9, anticorps gp9.L, anticorps Gp9

Sujet: Glycoprotein IX platelet,CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.,GPIX, GP9

ID gène: 2815

UniProt: P14770