CD160 anticorps (PE)

N° du produit ABIN1981901

Détail du produit anti-CD160 anticorps (PE)

Antigène: CD160

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD160 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody BY55 recognizes an extracellular epitope of CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Human NK cell line YT2C2

Clone: BY55

Isotype: IgM kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD160 (PE) (ABIN1981901)

Giustiniani, Bensussan, Marie-Cardine: "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 63-71, (2008) (PubMed).

Merino, Ramírez, Moreno, Toledo, Fernández, Sánchez-Ibarrola: "BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells." dans: Clinical and experimental immunology, Vol. 149, Issue 1, pp. 87-96, (2007) (PubMed).

Anumanthan, Bensussan, Boumsell, Christ, Blumberg, Voss, Patel, Robertson, Nadler, Freeman: "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 2780-90, (1998) (PubMed).

Bensussan, Gluckman, el Marsafy, Schiavon, Mansur, Dausset, Boumsell, Carosella: "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 19, pp. 9136-40, (1994) (PubMed).

Détails sur CD160

Antigène: CD160

Autre désignation: CD160 (CD160 Produits)

Synonymes: anticorps CD160, anticorps RGD1563598, anticorps BY55, anticorps AU045688, anticorps By55, anticorps NK1, anticorps NK28, anticorps CD160 molecule, anticorps CD160 antigen, anticorps CD160, anticorps Cd160

Sujet: CD160 Molecule,CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.,NK1, NK28

ID gène: 11126

UniProt: O95971