CNTNAP2 anticorps (C-Term)

N° du produit ABIN2017587

Détail du produit anti-CNTNAP2 anticorps

Antigène: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNTNAP2 est non-conjugé

Application: Veuillez nous consulter SVP

Specificité: Rabbit Anti-Caspr2 Polyclonal Antibody detects endogenous levels of mouse and rat Caspr2.

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): It is predicted to react with human Caspr2 according to sequence homology.
This product has not been tested for other species yet.

Attributs du produit: Rabbit Anti-Caspr2 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Caspr2 (Swiss Prot: Q9UHC6).

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from C-terminal of human Caspr2.

Isotype: IgG

Information d'application

Commentaires:

Positive Control: mouse brain and rat brain.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Concentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Références pour anticorps anti-CNTNAP2 (ABIN2017587)

Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." dans: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).

Détails sur CNTNAP2

Antigène: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Autre désignation: Caspr2 (CNTNAP2 Produits)

Synonymes: anticorps AUTS15, anticorps CASPR2, anticorps CDFE, anticorps NRXN4, anticorps PTHSL1, anticorps 5430425M22Rik, anticorps Caspr2, anticorps mKIAA0868, anticorps CASPR, anticorps MGC145769, anticorps MGC147944, anticorps MGC147981, anticorps contactin associated protein like 2, anticorps contactin associated protein-like 2, anticorps contactin associated protein like 2b, anticorps CNTNAP2, anticorps Cntnap2, anticorps cntnap2b, anticorps cntnap2

Sujet: Contacting-associated protein 2 (Caspr2) is a member of the neurexin superfamily that mediates nervous system cell-cell interactions. The C-terminal region of Caspr2 participates in the association with Kv1.1, Kv1.2 and their Kv-beta-2 subunit. Expression of Caspr2 is regulated directly by transcription factor FOXP2. Disruption or decreased expression of Caspr2 probably leads to a disturbed distribution of potassium channels in the nervous system. Mutations in the Caspr2 gene have been linked to many diseases such as focal epilepsy, autism spectrum disorder and cortical dysplasia-focal epilepsy syndrome (CDFES).

UniProt: Q9UHC6