ALOX15 anticorps (AA 581-662)

N° du produit ABIN2169710

Détail du produit anti-ALOX15 anticorps

Antigène: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Épitope: AA 581-662

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALOX15 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ALOX15 (ABIN2169710)

Francos-Quijorna, Amo-Aparicio, Martinez-Muriana, López-Vales: "IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury." dans: Glia, Vol. 64, Issue 12, pp. 2079-2092, (2016) (PubMed).

Détails sur ALOX15

Antigène: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Autre désignation: 15 Lipoxygenase 1 (ALOX15 Produits)

Synonymes: anticorps 15-LOX-1, anticorps 15LOX-1, anticorps ALOX15, anticorps 12-LO, anticorps Alox12l, anticorps L-12LO, anticorps 12-LOX, anticorps Alox12, anticorps ALOX12, anticorps 15-LOX, anticorps Alox12e, anticorps arachidonate 15-lipoxygenase, anticorps Arachidonate 15-lipoxygenase, anticorps ALOX15, anticorps Alox15, anticorps Nmul_A0532, anticorps Sden_1680, anticorps Swoo_2919, anticorps PCC8801_3106, anticorps Cyan8802_3014, anticorps Nwat_1315

Sujet:

Synonyms: 12-LOX, 15LOX-1, 15-LOX-1, Arachidonate 15-lipoxygenase, 15-LOX, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

ID gène: 246

UniProt: P16050

Pathways: Regulation of Actin Filament Polymerization