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ALOX15 anticorps (AA 581-662) (AbBy Fluor® 647)

ALOX15 Reactivité: Humain, Rat, Souris FACS, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN2169714
  • Antigène Voir toutes ALOX15 Anticorps
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    Épitope
    • 15
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 581-662
    Reactivité
    • 56
    • 24
    • 20
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Rat, Souris
    Hôte
    • 48
    • 10
    • 1
    Lapin
    Clonalité
    • 49
    • 10
    Polyclonal
    Conjugué
    • 27
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ALOX15 est conjugé à/à la AbBy Fluor® 647
    Application
    • 33
    • 16
    • 16
    • 13
    • 12
    • 12
    • 12
    • 10
    • 4
    • 4
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Cow,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1
    Isotype
    IgG
    Top Product
    Discover our top product ALOX15 Anticorps primaire
  • Indications d'application
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Dalli, Colas, Arnardottir, Serhan: "Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution." dans: Immunity, Vol. 46, Issue 1, pp. 92-105, (2017) (PubMed).

  • Antigène
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    Autre désignation
    15 Lipoxygenase 1 (ALOX15 Produits)
    Synonymes
    anticorps 15-LOX-1, anticorps 15LOX-1, anticorps ALOX15, anticorps 12-LO, anticorps Alox12l, anticorps L-12LO, anticorps 12-LOX, anticorps Alox12, anticorps ALOX12, anticorps 15-LOX, anticorps Alox12e, anticorps arachidonate 15-lipoxygenase, anticorps Arachidonate 15-lipoxygenase, anticorps ALOX15, anticorps Alox15, anticorps Nmul_A0532, anticorps Sden_1680, anticorps Swoo_2919, anticorps PCC8801_3106, anticorps Cyan8802_3014, anticorps Nwat_1315
    Sujet

    Synonyms: 12-LOX, 15LOX-1, 15-LOX-1, Arachidonate 15-lipoxygenase, 15-LOX, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15

    Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

    ID gène
    246
    UniProt
    P16050
    Pathways
    Regulation of Actin Filament Polymerization
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