ALOX15 anticorps (AA 581-662) (AbBy Fluor® 647)
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- Antigène Voir toutes ALOX15 Anticorps
- ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
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Épitope
- AA 581-662
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ALOX15 est conjugé à/à la AbBy Fluor® 647
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Application
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Cow,Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1
- Isotype
- IgG
- Top Product
- Discover our top product ALOX15 Anticorps primaire
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- Indications d'application
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution." dans: Immunity, Vol. 46, Issue 1, pp. 92-105, (2017) (PubMed).
: "
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Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution." dans: Immunity, Vol. 46, Issue 1, pp. 92-105, (2017) (PubMed).
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- Antigène
- ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
- Autre désignation
- 15 Lipoxygenase 1 (ALOX15 Produits)
- Synonymes
- anticorps 15-LOX-1, anticorps 15LOX-1, anticorps ALOX15, anticorps 12-LO, anticorps Alox12l, anticorps L-12LO, anticorps 12-LOX, anticorps Alox12, anticorps ALOX12, anticorps 15-LOX, anticorps Alox12e, anticorps arachidonate 15-lipoxygenase, anticorps Arachidonate 15-lipoxygenase, anticorps ALOX15, anticorps Alox15, anticorps Nmul_A0532, anticorps Sden_1680, anticorps Swoo_2919, anticorps PCC8801_3106, anticorps Cyan8802_3014, anticorps Nwat_1315
- Sujet
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Synonyms: 12-LOX, 15LOX-1, 15-LOX-1, Arachidonate 15-lipoxygenase, 15-LOX, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15
Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
- ID gène
- 246
- UniProt
- P16050
- Pathways
- Regulation of Actin Filament Polymerization
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