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STS anticorps

STS Reactivité: Humain, Souris, Rat WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2170333
  • Antigène Voir toutes STS Anticorps
    STS (Steroid Sulfatase (STS))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 33
    • 1
    Lapin
    Clonalité
    • 33
    • 1
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp STS est non-conjugé
    Application
    • 25
    • 12
    • 10
    • 10
    • 9
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Bactéries, Humain, Souris, Porc, Rat
    Homologie
    Dog,Cow,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human TMS1/ASC
    Isotype
    IgG
  • Indications d'application
    WB: 1:100-1000, FCM: 1:20-100, IHC-P: 1:100-500, IF(IHC-P): 1:50-200
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Fan, Yuan, Deng, Chen, Xie, Wu, Zhu, Xu, Huang, Yang, Zhang, Chen, Zhao: "Activation of Interleukin-1β Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes." dans: Frontiers in cellular and infection microbiology, Vol. 8, pp. 225, (2019) (PubMed).

    Zhang, Liu, Sui, Cai, Liu, Zhu, Yin: "Cortistatin inhibits NLRP3 inflammasome activation of cardiac fibroblasts during sepsis." dans: Journal of cardiac failure, (2015) (PubMed).

  • Antigène
    STS (Steroid Sulfatase (STS))
    Autre désignation
    Asc (STS Produits)
    Synonymes
    anticorps 9130417A21Rik, anticorps Asc, anticorps CARD5, anticorps TMS-1, anticorps TNS1, anticorps masc, anticorps ARSC, anticorps ARSC1, anticorps ASC, anticorps ES, anticorps SSDD, anticorps XLI, anticorps PYD and CARD domain containing, anticorps steroid sulfatase, anticorps Pycard, anticorps STS, anticorps Sts
    Sujet

    Synonyms: ASC, TMS, TMS1, CARD5, TMS-1, Apoptosis-associated speck-like protein containing a CARD, hASC, Caspase recruitment domain-containing protein 5, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, PYCARD

    Background: Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the DAPIN and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8.

    ID gène
    29108
    UniProt
    Q9ULZ3
    Pathways
    Steroid Hormone Biosynthesis, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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