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HCST anticorps (AA 19-48) (AbBy Fluor® 555)

HCST Reactivité: Humain, Rat WB, FACS, IF (p), IF (cc) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN2175294
  • Antigène Voir toutes HCST Anticorps
    HCST (Hematopoietic Cell Signal Transducer (HCST))
    Épitope
    AA 19-48
    Reactivité
    Humain, Rat
    Hôte
    • 15
    Lapin
    Clonalité
    • 15
    Polyclonal
    Conjugué
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HCST est conjugé à/à la AbBy Fluor® 555
    Application
    • 15
    • 13
    • 12
    • 12
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HCST
    Isotype
    IgG
    Top Product
    Discover our top product HCST Anticorps primaire
  • Indications d'application
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    HCST (Hematopoietic Cell Signal Transducer (HCST))
    Autre désignation
    Hcst (HCST Produits)
    Synonymes
    anticorps DAP10, anticorps KAP10, anticorps PIK3AP, anticorps Dap10, anticorps HCST, anticorps dap10, anticorps dap10-A, anticorps hcst, anticorps hcsta, anticorps kap10, anticorps pik3ap, anticorps hematopoietic cell signal transducer, anticorps hematopoietic cell signal transducer L homeolog, anticorps HCST, anticorps Hcst, anticorps hcst, anticorps hcst.L
    Sujet

    Synonyms: DAP10, KAP10, PIK3AP, Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10, Transmembrane adapter protein KAP10, HCST, UNQ587/PRO1157

    Background: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs), these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.

    ID gène
    10870
    UniProt
    Q9UBK5
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