IL1RAP anticorps (AA 251-350) (Biotin)

N° du produit ABIN2176997

Détail du produit anti-IL1RAP anticorps (Biotin)

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Épitope: AA 251-350

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1RAP est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris

Homologie: Human,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur IL1RAP

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Autre désignation: IL1RAP (IL1RAP Produits)

Synonymes: anticorps IL1RAP, anticorps il-1racp, anticorps il-racp, anticorps il1r3, anticorps C3orf13, anticorps IL-1RAcP, anticorps IL1R3, anticorps 6430709H04Rik, anticorps AI255955, anticorps AV239853, anticorps IL-1RAcp, anticorps Il1racpb, anticorps interleukin 1 receptor accessory protein, anticorps IL1RAP, anticorps il1rap, anticorps il-1racp, anticorps Il1rap

Sujet:

Synonyms: IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP

Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

ID gène: 3556

UniProt: Q9NPH3

Pathways: Signalisation NF-kappaB, Growth Factor Binding