IL1RAP anticorps (AA 251-350) (HRP)
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- Antigène Voir toutes IL1RAP Anticorps
- IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
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Épitope
- AA 251-350
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IL1RAP est conjugé à/à la HRP
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3
- Isotype
- IgG
- Top Product
- Discover our top product IL1RAP Anticorps primaire
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- Indications d'application
- IHC-P 1:200-400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
- Autre désignation
- IL1RAP (IL1RAP Produits)
- Synonymes
- anticorps IL1RAP, anticorps il-1racp, anticorps il-racp, anticorps il1r3, anticorps C3orf13, anticorps IL-1RAcP, anticorps IL1R3, anticorps 6430709H04Rik, anticorps AI255955, anticorps AV239853, anticorps IL-1RAcp, anticorps Il1racpb, anticorps interleukin 1 receptor accessory protein, anticorps IL1RAP, anticorps il1rap, anticorps il-1racp, anticorps Il1rap
- Sujet
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Synonyms: IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP
Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
- ID gène
- 3556
- UniProt
- Q9NPH3
- Pathways
- Signalisation NF-kappaB, Growth Factor Binding
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