OPTN anticorps (AA 341-440) (Biotin)

N° du produit ABIN2178068

Détail du produit anti-OPTN anticorps (Biotin)

Antigène: OPTN (Optineurin (OPTN))

Épitope: AA 341-440

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Optineurin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: Optineurin (OPTN Produits)

Synonymes: anticorps nrp, anticorps fip2, anticorps hip7, anticorps hypl, anticorps glc1e, anticorps tfiiia-intp, anticorps ALS12, anticorps FIP2, anticorps GLC1E, anticorps HIP7, anticorps HYPL, anticorps NRP, anticorps TFIIIA-INTP, anticorps Fip2, anticorps 4930441O07Rik, anticorps fj52f04, anticorps si:ch211-240l19.3, anticorps wu:fj52f04, anticorps zgc:66386, anticorps zgc:77868, anticorps optineurin, anticorps optineurin L homeolog, anticorps OPTN, anticorps optn, anticorps Optn, anticorps optn.L

Sujet:

Synonyms: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP, Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, OPTN

Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

ID gène: 10133

UniProt: Q96CV9

Pathways: M Phase