CD209a Antigen anticorps

N° du produit ABIN2191829

Détail du produit anti-CD209a Antigen anticorps

Antigène: CD209a Antigen (CD209A)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD209a Antigen est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

niveau d'endotoxine: Low endotoxin level

Clone: ER-TR9

Information d'application

Indications d'application: For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. 1

Restrictions: For Research Use only

Stockage

Buffer: 1 mL(> 200 μg/mL) culture medium with a low endotoxin level containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-CD209a Antigen (ABIN2191829)

Takagi, Numazaki, Kajiwara, Abe, Ishii, Kato, Kojima: "Cooperation of specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) and complement receptor type 3 (CR3) in the uptake of oligomannose-coated liposomes by macrophages." dans: Glycobiology, Vol. 19, Issue 3, pp. 258-66, (2009) (PubMed).

Nagaoka, Takahara, Tanaka, Yoshida, Steinman, Saitoh, Akashi-Takamura, Miyake, Kang, Park, Inaba: "Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria." dans: International immunology, Vol. 17, Issue 7, pp. 827-36, (2005) (PubMed).

Kang, Kim, Bruening, Pack, Charalambous, Pritsker, Moran, Loeffler, Steinman, Park: "The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 1, pp. 215-20, (2004) (PubMed).

Taylor, Brown, Herre, Williams, Willment, Gordon: "The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 2, pp. 1157-62, (2004) (PubMed).

Kretschmer, Jungebloud, Stopkowicz, Kleinke, Hoffmann, Weiss: "The selection of marginal zone B cells differs from that of B-1a cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 12, pp. 6495-501, (2003) (PubMed).

Détails sur CD209a Antigen

Antigène: CD209a Antigen (CD209A)

Autre désignation: Sign-r1 (CD209A Produits)

Synonymes: anticorps CD209, anticorps CDSIGN, anticorps CIRE, anticorps DC-SIGN, anticorps DC-SIGN1, anticorps Dcsign, anticorps SIGN-R1, anticorps SIGNR5, anticorps CD209a antigen, anticorps CD209a molecule, anticorps Cd209a

Sujet: The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1, a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C- terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood- borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages. Aliases CD209b, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 Immunogen Mouse thymic stromal cells