EPH Receptor B4 anticorps

N° du produit ABIN2191850

Détail du produit anti-EPH Receptor B4 anticorps

Antigène: EPH Receptor B4 (EPHB4)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp EPH Receptor B4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: VEB4-7E4

Information d'application

Indications d'application: For immunohistology, flow cytometry, immunofluorescence and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-EPH Receptor B4 (ABIN2191850)

Huang, Yamada, Kidoya, Naito, Nagahama, Kong, Katoh, Li, Ueno, Takakura: "EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis." dans: Cancer research, Vol. 67, Issue 20, pp. 9800-8, (2007) (PubMed).

Détails sur EPH Receptor B4

Antigène: EPH Receptor B4 (EPHB4)

Autre désignation: Ephrin Type-B Receptor 4 (EPHB4 Produits)

Synonymes: anticorps HTK, anticorps MYK1, anticorps TYRO11, anticorps htk, anticorps myk1, anticorps ephB4a, anticorps tyro11, anticorps ephb4b, anticorps MGC130997, anticorps AI042935, anticorps Htk, anticorps MDK2, anticorps Myk1, anticorps Tyro11, anticorps cb646, anticorps ephB4, anticorps rtk5, anticorps EphB-rtk8, anticorps cb417, anticorps rtk8, anticorps EPH receptor B4, anticorps EPH receptor B4 L homeolog, anticorps EPH receptor B4 S homeolog, anticorps Eph receptor B4, anticorps eph receptor B4a, anticorps eph receptor B4b, anticorps EPHB4, anticorps ephb4.L, anticorps ephb4.S, anticorps ephb4, anticorps Ephb4, anticorps ephb4a, anticorps ephb4b

Sujet: The monoclonal antibody VEB4-7E4 recognizes mouse Ephrin type-B receptor 4 (EphB4), an ~110 kD protein. Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell- extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo's, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well. The monoclonal antibody VEB4-7E4 marks venous endothelial cells, but not arterial endothelial cells in B16 melanoma cells. Aliases Tyrosine-protein kinase receptor HTK

Pathways: Signalisation RTK