TREM2 anticorps

N° du produit ABIN2191861

Détail du produit anti-TREM2 anticorps

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM2 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: 6E9

Information d'application

Indications d'application: For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-TREM2 (ABIN2191861)

Koga, Inui, Inoue, Kim, Suematsu, Kobayashi, Iwata, Ohnishi, Matozaki, Kodama, Taniguchi, Takayanagi, Takai: "Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis." dans: Nature, Vol. 428, Issue 6984, pp. 758-63, (2004) (PubMed).

Détails sur TREM2

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Autre désignation: Triggering Receptor Expressed On Myeloid Cells 2 (TREM2 Produits)

Synonymes: anticorps TREM-A1, anticorps TREM-B1, anticorps TREM2, anticorps trem-2, anticorps trem2a, anticorps trem2b, anticorps trem2c, anticorps TREM-2, anticorps Trem2a, anticorps Trem2b, anticorps Trem2c, anticorps triggering receptor expressed on myeloid cells 2, anticorps trem-like transcript 2 protein, anticorps TREM2, anticorps trem2, anticorps LOC100228399, anticorps Trem2

Sujet: The monoclonal antibody 6E9 recognizes mouse membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2). TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies. Aliases Triggering receptor expressed on monocytes 2, TREM2 Immunogen Mouse recombinant TREM-2 protein