MBP/MBL anticorps

N° du produit ABIN2191923

Détail du produit anti-MBP/MBL anticorps

Antigène: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBP/MBL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Blocking Reagent (BR), Immunoassay (IA)

Purification: Protein G

Stérilité: 0.2 μm filtered

niveau d'endotoxine: <24 EU/mg

Clone: 3E7

Information d'application

Indications d'application: For Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity dilutions have to be made according to the amounts MBL to be inactivated.

Restrictions: For Research Use only

Stockage

Buffer: PBS+0.1%BSA

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-MBP/MBL (ABIN2191923)

de Vries, Walter, Peutz-Kootstra, Wolfs, van Heurn, Buurman: "The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury." dans: The American journal of pathology, Vol. 165, Issue 5, pp. 1677-88, (2004) (PubMed).

Nauta, Castellano, Xu, Woltman, Borrias, Daha, van Kooten, Roos: "Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 5, pp. 3044-50, (2004) (PubMed).

Nauta, Raaschou-Jensen, Roos, Daha, Madsen, Borrias-Essers, Ryder, Koch, Garred: "Mannose-binding lectin engagement with late apoptotic and necrotic cells." dans: European journal of immunology, Vol. 33, Issue 10, pp. 2853-63, (2003) (PubMed).

Hisano, Matsushita, Fujita, Endo, Takebayashi: "Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis." dans: American journal of kidney diseases : the official journal of the National Kidney Foundation, Vol. 38, Issue 5, pp. 1082-8, (2001) (PubMed).

Matsushita, Takahashi, Hatsuse, Kawakami, Fujita: "Human mannose-binding protein is identical to a component of Ra-reactive factor." dans: Biochemical and biophysical research communications, Vol. 183, Issue 2, pp. 645-51, (1992) (PubMed).

Détails sur MBP/MBL

Antigène: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Autre désignation: Mbl (MBP/MBL Produits)

Synonymes: anticorps COLEC1, anticorps HSMBPC, anticorps MBL, anticorps MBL2D, anticorps MBP, anticorps MBP-C, anticorps MBP1, anticorps MBPD, anticorps pMBP-27, anticorps MBL1, anticorps cMBl, anticorps collectin, anticorps L-MBP, anticorps MBL-C, anticorps RaRF p28A, anticorps mbl, anticorps mannose binding lectin 2, anticorps mannose-binding lectin (protein C) 2, anticorps mannose-binding protein C-like, anticorps MBL2, anticorps Mbl2, anticorps LOC100911854

Sujet: Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N- acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.