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C3 anticorps

C3 Reactivité: Humain WB, FACS, IA Hôte: Souris Monoclonal 755 unconjugated
N° du produit ABIN2191942
  • Antigène Voir toutes C3 Anticorps
    C3 (Complement Component 3 (C3))
    Reactivité
    • 96
    • 52
    • 33
    • 5
    • 4
    • 4
    • 3
    • 3
    Humain
    Hôte
    • 69
    • 45
    • 28
    • 8
    • 7
    • 5
    Souris
    Clonalité
    • 126
    • 35
    Monoclonal
    Conjugué
    • 69
    • 25
    • 20
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp C3 est non-conjugé
    Application
    • 98
    • 47
    • 37
    • 36
    • 33
    • 29
    • 29
    • 28
    • 22
    • 18
    • 13
    • 13
    • 12
    • 9
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoassay (IA)
    Réactivité croisée (Details)
    Cross reactivity: Human C3a : No
    Stérilité
    0.2 μm filtered
    Clone
    755
    Isotype
    IgG1
    Top Product
    Discover our top product C3 Anticorps primaire
  • Indications d'application
    For Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Human serum control Negative C3 deficient serum control
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Hawlisch, Meyer zu Vilsendorf, Bautsch, Klos, Köhl: "Guinea pig C3 specific rabbit single chain Fv antibodies from bone marrow, spleen and blood derived phage libraries." dans: Journal of immunological methods, Vol. 236, Issue 1-2, pp. 117-31, (2000) (PubMed).

    Klos, Ihrig, Messner, Grabbe, Bitter-Suermann: "Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies." dans: Journal of immunological methods, Vol. 111, Issue 2, pp. 241-52, (1988) (PubMed).

  • Antigène
    C3 (Complement Component 3 (C3))
    Autre désignation
    c3/c3b (C3 Produits)
    Synonymes
    anticorps AHUS5, anticorps ARMD9, anticorps ASP, anticorps C3a, anticorps C3b, anticorps CPAMD1, anticorps AI255234, anticorps HSE-MSF, anticorps Plp, anticorps C3, anticorps C3-1, anticorps sb:cb26, anticorps si:dkey-76b14.4, anticorps wu:fi34b03, anticorps wu:fj86e11, anticorps C3d, anticorps asp, anticorps cpamd1, anticorps c3, anticorps complement C3, anticorps complement component 3, anticorps complement component c3a, duplicate 1, anticorps complement component 3 L homeolog, anticorps complement component C3, anticorps complement C3-like, anticorps C3, anticorps c3a.1, anticorps c3.L, anticorps LOC443475, anticorps c3, anticorps c3-1, anticorps LOC100060539
    Sujet
    The monoclonal antibody 755 recognizes an epitope located in the C-terminal 360 amino acids on the alpha chain of C3, thereby recognizing C3b and full C3. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes a person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody- mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. After activation of the complement system, certain enzymes become active, resulting in the cleavage of C3 into C3b and the anaphylatoxin C3a. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f. Within the alternative pathway of complement, C3b plays a critical role in the amplification loop initiated by spontaneous hydrolysis of C3. Aliases Complement component 3 Immunogen Native C3
    Pathways
    Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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