JUP anticorps

N° du produit ABIN2191996

Détail du produit anti-JUP anticorps

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Stérilité: 0.2 μm filtered

Clone: 15F11

Information d'application

Indications d'application: For Western blotting and immunofluorescence dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-JUP (ABIN2191996)

Amitay, Nass, Meitar, Goldberg, Davidson, Trakhtenbrot, Brok-Simoni, Ben-Zeev, Rechavi, Kaufmann: "Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma." dans: The American journal of pathology, Vol. 159, Issue 1, pp. 43-9, (2001) (PubMed).

Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: "Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains." dans: Journal of cell science, Vol. 109 ( Pt 5), pp. 1143-54, (1996) (PubMed).

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Plakoglobin (JUP Produits)

Synonymes: anticorps ARVD12, anticorps CTNNG, anticorps DP3, anticorps DPIII, anticorps PDGB, anticorps PKGB, anticorps arvd12, anticorps ctnng, anticorps dp3, anticorps dpiii, anticorps pdgb, anticorps pkgb, anticorps plak, anticorps D930025P04Rik, anticorps PG, anticorps cb80, anticorps danPG, anticorps fb11b06, anticorps jup, anticorps wu:fb11b06, anticorps junction plakoglobin, anticorps junction plakoglobin L homeolog, anticorps Junction plakoglobin, anticorps junction plakoglobin a, anticorps junction plakoglobin S homeolog, anticorps JUP, anticorps Jup, anticorps jup, anticorps jup.L, anticorps Tsp_06656, anticorps plak, anticorps jupa, anticorps jup.S

Sujet: Plakoglobin, also known as gamma-catenin belongs together with alpha- and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas. The monoclonal antibody 15F11 cross reacts with rat and weakly with mouse.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location