CD96 anticorps

N° du produit ABIN2192060

Détail du produit anti-CD96 anticorps

Antigène: CD96

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD96 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Stérilité: 0.2 μm filtered

Clone: NK92-39

Information d'application

Indications d'application: For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies in vitro dilutions have to be made according to the amounts of CD96 to be inactivated.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-CD96 (ABIN2192060)

Fuchs, Cella, Giurisato, Shaw, Colonna: "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 3994-8, (2004) (PubMed).

Détails sur CD96

Antigène: CD96

Autre désignation: CD96 (CD96 Produits)

Synonymes: anticorps 1700109I12Rik, anticorps Tactile, anticorps TACTILE, anticorps CD96 antigen, anticorps CD96 molecule, anticorps Cd96, anticorps CD96

Sujet: The monoclonal antibody NK92.39 reacts with CD96, also known as T cell-Activated Increased Late Expression (Tactile). CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR/CD155). Furthermore, CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells. This mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. The monoclonal antibody NK92.39 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.