PLVAP anticorps

N° du produit ABIN2192062

Détail du produit anti-PLVAP anticorps

Antigène: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PLVAP est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Stérilité: 0.2 μm filtered

Clone: 174-2

Information d'application

Indications d'application: For immunohistology, flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-PLVAP (ABIN2192062)

Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." dans: Blood, Vol. 106, Issue 10, pp. 3405-9, (2005) (PubMed).

Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, (2005) (PubMed).

Détails sur PLVAP

Antigène: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Autre désignation: Plasmalemma Vesicle Associated Protein (PLVAP Produits)

Synonymes: anticorps MECA32, anticorps Pv1, anticorps FELS, anticorps PV-1, anticorps PV1, anticorps gp68, anticorps plasmalemma vesicle associated protein, anticorps Plvap, anticorps PLVAP

Sujet: The monoclonal antibody 174/2 reacts with human plasmalemma vesicle associated protein (PLVAP), also known as PV1, PAL-E and FELS. PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.