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C5a Receptor anticorps

C5AR Reactivité: Rat FACS, WB, IHC (fro) Hôte: Souris Monoclonal R63 unconjugated
N° du produit ABIN2192106
  • Antigène Tous les produits C5a Receptor (C5AR)
    C5a Receptor (C5AR)
    Reactivité
    Rat
    Hôte
    • 2
    Souris
    Clonalité
    • 2
    Monoclonal
    Conjugué
    • 2
    Cet anticorp C5a Receptor est non-conjugé
    Application
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Stérilité
    0.2 μm filtered
    Clone
    R63
  • Indications d'application
    For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Crane, Baiquni, Sullivan, Lee, Sah, Taylor, Noakes, Woodruff: "The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres." dans: Journal of neuroinflammation, Vol. 6, pp. 34, (2009) (PubMed).

    Woodruff, Costantini, Crane, Atkin, Monk, Taylor, Noakes: "The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 12, pp. 8727-34, (2008) (PubMed).

    Griffin, Costigan, Brenner, Ma, Scholz, Moss, Allchorne, Stahl, Woolf: "Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 32, pp. 8699-708, (2007) (PubMed).

    Schieferdecker, Schlaf, Koleva, Götze, Jungermann: "Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5453-8, (2000) (PubMed).

  • Antigène
    C5a Receptor (C5AR)
    Autre désignation
    c5a Receptor (C5AR Produits)
    Sujet
    The monoclonal antibody R63 reacts with the rat receptor for C5a (CD88). The rat anaphylatoxin C5a is a 77-amino acid glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a has been demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP-binding-protein- coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by myeloid cells including Kupfer cells. Using immunohistology there is no evidence for non-myeloid expression in healthy control rats. Under inflammatory situations however the C5aR was found to be upregulated in various organs and tissues including the liver. Aliases C5aR, CD88, C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin receptor, C5a ligand, C5a- R, complement component 5a receptor 1 Immunogen RBH-2H3 cells transfected with rat C5aR gene
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