DPP4
Reactivité: Humain, Souris
WB, IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Date de péremption
12 months
Ariyoshi, Mizuno, Morisue, Shimada, Fujita, Nasu, Okada, Shimomura, Yamamoto, Tsuji: "Identification of a target antigen recognized by a mouse monoclonal antibody to the bile canalicular surface of rat hepatocytes with a random phage display library." dans: Acta medica Okayama, Vol. 56, Issue 4, pp. 187-91, (2002) (PubMed).
Hyodo, Mizuno, Yamada, Tsuji: "Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma." dans: Liver, Vol. 13, Issue 2, pp. 80-5, (1993) (PubMed).
Mizuno, Yamada, Sugiyama, Vierling, Brown: "Monoclonal antibodies identifying antigens on distinct domains of rat hepatocytes." dans: Liver, Vol. 7, Issue 5, pp. 251-9, (1988) (PubMed).
Dipeptidyl peptidase IV (DPP IV) is widely distributed in a number of mammalian tissues and is suggested to play an important role in various kinds of biological processes. DPP IV (CD26) is a serine-type protease that removes the amino-terminal dipeptide from peptide substrate provided that the penultimate amino acid residue is proline or alanine. DPP IV plays an important role in the reclamation of peptide nitrogen from larger peptides. The monoclonal antibody 5E8 reacts with DPP IV present on the apical surface of epithelial cells in the pancreas, small intestine, colon, and bile duct. Furthermore antibody 5E8 reacts with DPP IV on the laminar portions of the proximal renal tubule cells, and, weakly, on the glomeruli.