SFTPD anticorps

N° du produit ABIN2192111

Détail du produit anti-SFTPD anticorps

Antigène: SFTPD (Surfactant Protein D (SFTPD))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SFTPD est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: IIIH3

Information d'application

Indications d'application: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-SFTPD (ABIN2192111)

ter Horst, Fijlstra, Sengupta, Walther, Wagenaar: "Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury." dans: BMC pulmonary medicine, Vol. 6, pp. 8, (2006) (PubMed).

Kasper, Albrecht, Grossmann, Grosser, Schuh, Müller: "Monoclonal antibodies to surfactant protein D: evaluation of immunoreactivity in normal rat lung and in a radiation-induced fibrosis model." dans: Experimental lung research, Vol. 21, Issue 4, pp. 577-88, (1995) (PubMed).

Détails sur SFTPD

Antigène: SFTPD (Surfactant Protein D (SFTPD))

Autre désignation: Surfactant Protein D (SFTPD Produits)

Synonymes: anticorps COLEC7, anticorps PSP-D, anticorps SFTP4, anticorps SP-D, anticorps BDE, anticorps BDSD, anticorps HOX4I, anticorps SPD, anticorps AI573415, anticorps Sftp4, anticorps surfactant protein D, anticorps homeobox D13, anticorps surfactant associated protein D, anticorps SFTPD, anticorps HOXD13, anticorps Sftpd, anticorps SP-D

Sujet: The monoclonal antibody IIIH3 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody IIIH3 specific for rat surfactant protein D shows significant cross reactivity with human SP-D.