BCR anticorps

N° du produit ABIN2192147

Détail du produit anti-BCR anticorps

Antigène: BCR (Breakpoint Cluster Region (BCR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCR est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)

Réactivité croisée (Details): Cross reactivity: Multispecies : Yes

Stérilité: 0.2 μm filtered

Clone: CML26

Isotype: IgG1

Information d'application

Indications d'application: For immunohistochemistry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Intramyocardial arteries control

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-BCR (ABIN2192147)

Bruynzeel, Abou El Hassan, Schalkwijk, Berkhof, Bast, Niessen, van der Vijgh: "Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice." dans: British journal of cancer, Vol. 96, Issue 6, pp. 937-43, (2007) (PubMed).

Ciapaite, Bakker, Van Eikenhorst, Wagner, Teerlink, Schalkwijk, Fodor, Ouwens, Diamant, Heine, Westerhoff, Krab: "Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats." dans: Biochimica et biophysica acta, Vol. 1772, Issue 3, pp. 307-16, (2007) (PubMed).

Baidoshvili, Krijnen, Kupreishvili, Ciurana, Bleeker, Nijmeijer, Visser, Visser, Meijer, Stooker, Eijsman, van Hinsbergh, Hack, Niessen, Schalkwijk: "N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?" dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 11, pp. 2497-503, (2006) (PubMed).

van Heijst, Niessen, Musters, van Hinsbergh, Hoekman, Schalkwijk: "Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis." dans: Cancer letters, Vol. 241, Issue 2, pp. 309-19, (2006) (PubMed).

Sommeijer, Beganovic, Schalkwijk, Ploegmakers, van der Loos, van Aken, ten Cate, van der Wal: "More fibrosis and thrombotic complications but similar expression patterns of markers for coagulation and inflammation in symptomatic plaques from DM2 patients." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 52, Issue 9, pp. 1141-9, (2004) (PubMed).

Détails sur BCR

Antigène: BCR (Breakpoint Cluster Region (BCR))

Autre désignation: Cml (BCR Produits)

Synonymes: anticorps si:dkey-83d9.7, anticorps zK83D9.7, anticorps BCR, anticorps ALL, anticorps BCR1, anticorps CML, anticorps D22S11, anticorps D22S662, anticorps PHL, anticorps 5133400C09Rik, anticorps AI561783, anticorps AI853148, anticorps mKIAA3017, anticorps breakpoint cluster region, anticorps BCR, RhoGEF and GTPase activating protein, anticorps bcr, anticorps BCR, anticorps Bcr

Sujet: The monoclonal antibody CML26 recognizes human CML (carboxymethyl-lysine). CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications. Immunogen CML-KLH

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling