BPI anticorps
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- Antigène Voir toutes BPI Anticorps
- BPI (Bactericidal/Permeability Increasing Protein (BPI))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BPI est non-conjugé
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Application
- ELISA, Immunoprecipitation (IP)
- Stérilité
- 0.2 μm filtered
- Top Product
- Discover our top product BPI Anticorps primaire
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- Indications d'application
- The antibody is useful for immuno precipitation. Furthermore the antibody is useful to detect BPI in ELISA both as coating and as detector.
- Restrictions
- For Research Use only
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- Buffer
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- Date de péremption
- 12 months
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- Antigène
- BPI (Bactericidal/Permeability Increasing Protein (BPI))
- Autre désignation
- Bactericidal Permeability Increasing Protein (BPI Produits)
- Synonymes
- anticorps 9230105K17Rik, anticorps Bpifd1, anticorps BPIFD1, anticorps rBPI, anticorps bpi, anticorps bpi.L, anticorps lbp, anticorps bactericidal/permeability-increasing protein, anticorps bactericidal permeablility increasing protein, anticorps bactericidal/permeability-increasing protein S homeolog, anticorps BPI, anticorps Bpi, anticorps bpi.S
- Sujet
- The polyclonal antibody reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti- infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS- triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The polyclonal antibody recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
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