TP53BP2 anticorps (Internal Region)

N° du produit ABIN233802

Détail du produit anti-TP53BP2 anticorps

Antigène: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TP53BP2 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP2.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 125 kDa in size corresponding to ASPP2 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.4 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TP53BP2

Antigène: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Autre désignation: ASPP2 (TP53BP2 Produits)

Synonymes: anticorps 53BP2, anticorps ASPP2, anticorps BBP, anticorps P53BP2, anticorps PPP1R13A, anticorps TP53BP2, anticorps AI746547, anticorps Tp53bp2, anticorps X98550, anticorps Trp53bp2, anticorps wu:fa09h08, anticorps wu:fb04e08, anticorps zgc:85720, anticorps tumor protein p53 binding protein 2, anticorps tumor protein p53 binding protein 2 L homeolog, anticorps tumor protein p53 binding protein, 2b, anticorps transformation related protein 53 binding protein 2, anticorps tumor protein p53 binding protein, 2, anticorps tumor protein p53 binding protein, 2a, anticorps TP53BP2, anticorps tp53bp2.L, anticorps tp53bp2, anticorps tp53bp2b, anticorps Trp53bp2, anticorps Tp53bp2, anticorps tp53bp2a

Sujet: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody

ID gène: 7159, 112799849

UniProt: Q13625