PPP1R13B anticorps (Internal Region)

N° du produit ABIN233830

Détail du produit anti-PPP1R13B anticorps

Antigène: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R13B est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur PPP1R13B

Antigène: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Autre désignation: ASPP1 (PPP1R13B Produits)

Synonymes: anticorps ASPP1, anticorps p53BP2-like, anticorps p85, anticorps AI449786, anticorps AW545810, anticorps Tp53bp2, anticorps Trp53bp2, anticorps protein phosphatase 1 regulatory subunit 13B, anticorps protein phosphatase 1, regulatory subunit 13B, anticorps protein phosphatase 1 regulatory subunit 13B L homeolog, anticorps protein phosphatase 1, regulatory subunit 13Bb, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 13B, anticorps PPP1R13B, anticorps Ppp1r13b, anticorps ppp1r13b.L, anticorps ppp1r13bb, anticorps ppp1r13b

Sujet: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: p53BP2 like antibody, p85 antibody, PPP1R13B antibody

ID gène: 23368, 121114287

UniProt: Q62415

Pathways: Signalisation p53