Selenoprotein W anticorps

N° du produit ABIN233833

Détail du produit anti-Selenoprotein W anticorps

Antigène: Selenoprotein W (SEPW1) (Selenoprotein W, 1 (SEPW1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Selenoprotein W est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific for mouse Selenoprotein W.  A BLAST analysis was used to suggest cross-reactivity with SelW from rat based on a 98% homology with the immunizing sequence.  Partial reactivity is expected against human-derived SelW based on an 87% homology with the immunogen.  Cross-reactivity with SelW from other sources has not been determined.

Attributs du produit: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Selenoprotein W was first purified and characterized from rat skeletal muscle. The function of selenoprotein W is not entirely clear, but the presence of the bound glutathione moiety indicates that SelW is thought to function in oxidation-reduction catalysis and may play a role in selenium deficiency disorders such as white muscle disease in sheep and Keshan disease in humans. Recently, overexpression of SelW was shown to be glutathione dependent and was shown to markedly reduce the sensitivity of cell lines to H₂O₂ cytotoxicity.

Purification: affinity purified

Stérilité: Sterile filtered

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to full-length mouse SelW protein.
Immunogen Type: RecombinantProtein

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 9.6 kDa in size corresponding to SelW by western blotting in the appropriate cell lysate or extract.  This antibody is capable of detecting both overexpressed and endogenous SelW.

Commentaires:

Gene Name: SEPW1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.38 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

Date de péremption: 3 months

Détails sur Selenoprotein W

Antigène: Selenoprotein W (SEPW1) (Selenoprotein W, 1 (SEPW1))

Autre désignation: Selenoprotein W (SEPW1 Produits)

Synonymes: anticorps SEPW1, anticorps sepw1, anticorps selw1, anticorps SelW, anticorps selW, anticorps SEPW, anticorps cb694, anticorps fe37b06, anticorps wu:fe37b06, anticorps wu:fk70h03, anticorps zgc:109781, anticorps selenoprotein W, anticorps selenoprotein W, 1, anticorps SELENOW, anticorps sepw1, anticorps Selenow, anticorps SEPW1, anticorps selenow1

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Selenoprotein W was first purified and characterized from rat skeletal muscle.  The function of selenoprotein W is not entirely clear, but the presence of the bound glutathione moiety indicates that SelW is thought to function in oxidation–reduction catalysis and may play a role in selenium deficiency disorders such as white muscle disease in sheep and Keshan disease in humans. Recently, overexpression of SelW was shown to be glutathione dependent and was shown to markedly reduce the sensitivity of cell lines to H₂O₂ cytotoxicity.
Synonyms: Selenoprotein W SelW

ID gène: 20364, 2384723

UniProt: P63300

Pathways: Cell RedoxHomeostasis