ATR anticorps (Internal Region)
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- Antigène Voir toutes ATR Anticorps
- ATR (ATR serine/threonine kinase (ATR))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATR est non-conjugé
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Application
- ELISA, Western Blotting (WB)
- Réactivité croisée
- Souris, Rat (Rattus), Singe, Chien, Poisson, Xenopus laevis
- Attributs du produit
- Concentration Definition: by UV absorbance at 280 nm
- Immunogène
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an of human ATR protein.
- Isotype
- IgG
- Top Product
- Discover our top product ATR Anticorps primaire
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- Indications d'application
- This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 301 kDa in size corresponding to ATR by western blotting in the appropriate cell lysate or extract. Lysates from HeLa, U2OS, RAW264.7 or HEK293 cells are suggested for western blotting. ATR is ubiquitously expressed, with highest expression levels in the testes. Note that isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.28 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- ATR (ATR serine/threonine kinase (ATR))
- Autre désignation
- ATR (ATR Produits)
- Synonymes
- anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr
- Sujet
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Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidyl-inositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4). ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types. ATR is recruited to chromatin during S-phase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Synonyms: ACTR antibody, AIB1 antibody, amplified in breast cancer 1 antibody, Ataxia Telangiecasia and Rad3 Related antibody, CAGH16 antibody, CBP interacting protein antibody, CTG26 antibody, FRAP Related Protein 1 antibod - ID gène
- 545, 157266317
- UniProt
- Q13535
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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