GLO1 anticorps (full length)

N° du produit ABIN2451990

Détail du produit anti-GLO1 anticorps

Antigène: GLO1 (Glyoxalase I (GLO1))

Épitope: full length

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp GLO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunochromatography (IC)

Specificité: Specific to human, simian, and mouse glyoxalase I.

Réactivité croisée (Details): Not tested in other species.

Attributs du produit: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Recombinant GST-fused mouse glyoxalase I (full length)

Clone: 6F10

Isotype: IgG2b kappa

Information d'application

Indications d'application: 1. Western blotting: ~ 1,000
2. Immunocytochemistry
3. ELISA
Other applications are not tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C/-80 °C

Stockage commentaire: -20 C (For long term storage: -70 C)

Références pour anticorps anti-GLO1 (ABIN2451990)

Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." dans: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).

Chen, Wollmer, Hoerndli, Münch, Kuhla, Rogaev, Tsolaki, Papassotiropoulos, Götz: "Role for glyoxalase I in Alzheimer's disease." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).

Junaid, Kowal, Barua, Pullarkat, Sklower Brooks, Pullarkat: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." dans: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).

Détails sur GLO1

Antigène: GLO1 (Glyoxalase I (GLO1))

Autre désignation: Glyoxalase 1 (GLO1) (GLO1 Produits)

Synonymes: anticorps GLOD1, anticorps GLYI, anticorps 0610009E22Rik, anticorps 1110008E19Rik, anticorps 2510049H23Rik, anticorps AW550643, anticorps GLY1, anticorps Glo-1, anticorps Glo-1r, anticorps Glo-1s, anticorps Glo1-r, anticorps Glo1-s, anticorps Qglo, anticorps cb554, anticorps zgc:66035, anticorps wu:fb82g09, anticorps glod1, anticorps glyi, anticorps glo1, anticorps GLO1, anticorps ATGLX1, anticorps F12F1.32, anticorps F12F1_32, anticorps GLYOXALASE I, anticorps glyoxalase I homolog, anticorps trypanothione-dependent glyoxalase I, anticorps glyoxalase I, anticorps glyoxalase 1, anticorps glyoxalase 1 L homeolog, anticorps glyoxalase 1 S homeolog, anticorps lactoylglutathione lyase, anticorps glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein, anticorps GLO1, anticorps Glo1, anticorps glo1, anticorps glo1.L, anticorps glo1.S, anticorps GST3, anticorps GLX1, anticorps STY1687, anticorps Bcen_2094, anticorps gloA

Sujet: Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

UniProt: Q9CPU0