NUP98 anticorps (FGxxN Motif, N-Term)

N° du produit ABIN2452065

Détail du produit anti-NUP98 anticorps

Antigène: NUP98 (Nucleoporin 98kDa (NUP98))

Épitope: FGxxN Motif, N-Term

Reactivité: Humain, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUP98 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée (Details): Not tested in other species

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Synthetic peptides containing conserved N-terminal sequence, GLFG, of Nup98 protein of Tetrahymena thermophila.

Clone: 13C2

Isotype: IgG1 kappa

Information d'application

Indications d'application: 1) Most suitable for Western blotting,(Human,S. cerevisiae,S. pombe,Tetrahymena.)
2) Immunofluorescence staining / Immunocytochemistry for S. cerevisiae,S. pombe and T. etrahymena.
Not suitable for IF in human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol. Azide- and carrier protein-free.

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Upon arrival centrifuge briefly and store at -20 C.

Références pour anticorps anti-NUP98 (ABIN2452065)

Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." dans: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).

Iwamoto, Asakawa, Hiraoka, Haraguchi: "Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 661-9, (2010) (PubMed).

Détails sur NUP98

Antigène: NUP98 (Nucleoporin 98kDa (NUP98))

Autre désignation: Nup98 (NUP98 Produits)

Sujet: Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on both nuclear and cytoplasmic side of NPC. This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In addition, Nup98 plays roles in several important biological events such as gene expression, mitotic checkpoint, and pathogenesis Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal translocation. In ciliates, a unicellular organism having two functionally distinct nuclei, GLFG-Nup98 is present in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these different Nup98s participate in a nucleus-selective transport mechanism.

UniProt: P52948

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome