RAD18 anticorps (C-Term)

N° du produit ABIN2452086

Détail du produit anti-RAD18 anticorps

Antigène: RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD18 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée (Details): Not reactive to mouse Rad18

Purification: Affinity purified with His-tagged Rad18 protein affinity column

Immunogène: GST-fusion protein containing 113 carboxyl terminal of human Rad18

Isotype: IgG

Information d'application

Indications d'application: 1) Western blotting: 1,000 fold dilution
2) Indirect immunofluorescence staining
3) Immunoprecipitation

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C

Références pour anticorps anti-RAD18 (ABIN2452086)

Watanabe, Tateishi, Kawasuji, Tsurimoto, Inoue, Yamaizumi: "Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination." dans: The EMBO journal, Vol. 23, Issue 19, pp. 3886-96, (2004) (PubMed).

Miyase, Tateishi, Watanabe, Tomita, Suzuki, Inoue, Yamaizumi: "Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination." dans: The Journal of biological chemistry, Vol. 280, Issue 1, pp. 515-24, (2004) (PubMed).

Tateishi, Sakuraba, Masuyama, Inoue, Yamaizumi: "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7927-32, (2000) (PubMed).

Détails sur RAD18

Antigène: RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))

Autre désignation: Rad18 (RAD18 Produits)

Synonymes: anticorps RNF73, anticorps 2810024C04Rik, anticorps Rad18sc, anticorps zgc:55577, anticorps RAD18, anticorps DDBDRAFT_0218120, anticorps DDBDRAFT_0304878, anticorps DDB_0218120, anticorps DDB_0304878, anticorps DKFZp469H0810, anticorps RAD18, E3 ubiquitin protein ligase, anticorps RAD18 E3 ubiquitin protein ligase, anticorps E3 ubiquitin-protein ligase RAD18, anticorps E3 ubiquitin-protein ligase, anticorps DNA repair protein and ATPase, anticorps C3HC4-type zinc finger-containing protein, anticorps RAD18, anticorps Rad18, anticorps rad18

Sujet: The Rad6-Rad18 pair of genes plays a critical role in post-replication repair of damaged DNA. Rad6 protein functions as an E2 enzyme and Rad18 (495 aa, 56 kDa) as an ubiquitine ligase (E3) which ubiquitinates PCNA. Rad18 recruits translesion DNA polymerases to damaged DNA.