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PSMD8 anticorps

PSMD8 Reactivité: Saccharomyces cerevisiae WB, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2452112
  • Antigène Voir toutes PSMD8 Anticorps
    PSMD8 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 (PSMD8))
    Reactivité
    • 36
    • 24
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Saccharomyces cerevisiae
    Hôte
    • 33
    • 3
    Lapin
    Clonalité
    • 35
    • 1
    Polyclonal
    Conjugué
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PSMD8 est non-conjugé
    Application
    • 26
    • 13
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Purification
    Affinity purified
    Immunogène
    Recombinant yeast Rpn12 expressed in E. coli
    Isotype
    IgG
    Top Product
    Discover our top product PSMD8 Anticorps primaire
  • Indications d'application
    1) Western blotting: 1/5,000~1/10,000
    2) Immunoprecipitation
    Other applications have not been tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, 1 mg/mL BSA, 0.09 % sodium azide, 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Tone, Tanahashi, Tanaka, Fujimuro, Yokosawa, Toh-e: "Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells." dans: Gene, Vol. 243, Issue 1-2, pp. 37-45, (2000) (PubMed).

    Takeuchi, Toh-e et al.: "Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic ..." dans: Molecular & general genetics : MGG, Vol. 262, Issue 1, pp. 145-53, (1999) (PubMed).

    Hershko, Ciechanover: "The ubiquitin system." dans: Annual review of biochemistry, Vol. 67, pp. 425-79, (1998) (PubMed).

  • Antigène
    PSMD8 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 (PSMD8))
    Autre désignation
    Rpn12 (PSMD8 Produits)
    Sujet
    Background: The 26 S proteasome is a protein complex with a molecular mass of 2,000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation, DNA repair, signal transduction, apoptosis, and metabolic regulation. The 26S proteasome is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP is further subdivided into lid and base sub-complexes. Rpn12 is one of the non-ATPase subunits of the lid. Rpn12 interacts with an ATPase subunit, Rpt1, of the base. Rpn12, Rpt1 double mutant becomes lethal, suggesting a strong interaction between Rpn12 and Rpt1. In the double mutant cells, the function of the 26S proteasome is completely eliminated.
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Proton Transport, Synthesis of DNA, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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