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SUMO2/3 anticorps (full length)

SUMO2/3 Reactivité: Humain, Souris, Rat WB, IF, ELISA, IHC (fro) Hôte: Rat Monoclonal 3H12 unconjugated
N° du produit ABIN2452139
  • Antigène Tous les produits SUMO2/3
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Épitope
    • 16
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    Reactivité
    • 48
    • 13
    • 13
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 10
    Rat
    Clonalité
    • 30
    • 18
    Monoclonal
    Conjugué
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SUMO2/3 est non-conjugé
    Application
    • 41
    • 24
    • 14
    • 14
    • 14
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.
    Réactivité croisée (Details)
    Not tested for other species
    Purification
    The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
    Stérilité
    Sterile filtered
    Immunogène
    Recombinant GST-fused human SUMO3 (full length)
    Clone
    3H12
    Isotype
    IgG2a kappa
  • Indications d'application
    1. Western blotting: 1/1,000
    2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
    3. Immunohistochemistry,frozen section: 1/100~1/500
    4. ELISA (Assay dependent concentration)
    Other applications have not been tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (x1), 50 % glycerol. Azide and carrier free.
    Agent conservateur
    Azide free
    Stock
    -20 °C
    Stockage commentaire
    Upon arrival centrifuge briefly and store at -20 C.
  • Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." dans: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

  • Antigène
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Autre désignation
    SUMO2/3 (SUMO2/3 Produits)
    Synonymes
    anticorps SUMO2, anticorps small ubiquitin-like modifier 2, anticorps SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like, anticorps small ubiquitin-related modifier 2, anticorps SUMO2, anticorps LOC711990, anticorps LOC714892
    Sujet
    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.
    Poids moléculaire
    10,871 Da with 95 AA, 11,637 Da with 103 AA
    UniProt
    P61956, P55854
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