SUMO2/3 anticorps (full length)

N° du produit ABIN2452139

Détail du produit anti-SUMO2/3 anticorps

Antigène: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Épitope: full length

Reactivité: Humain, Souris, Rat

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp SUMO2/3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.

Réactivité croisée (Details): Not tested for other species

Purification: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Stérilité: Sterile filtered

Immunogène: Recombinant GST-fused human SUMO3 (full length)

Clone: 3H12

Isotype: IgG2a kappa

Information d'application

Indications d'application: 1. Western blotting: 1/1,000
2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
3. Immunohistochemistry,frozen section: 1/100~1/500
4. ELISA (Assay dependent concentration)
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (x1), 50 % glycerol. Azide and carrier free.

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Upon arrival centrifuge briefly and store at -20 C.

Références pour anticorps anti-SUMO2/3 (ABIN2452139)

Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." dans: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

Détails sur SUMO2/3

Antigène: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Autre désignation: SUMO2/3 (SUMO2/3 Produits)

Synonymes: anticorps SUMO2, anticorps small ubiquitin-like modifier 2, anticorps SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like, anticorps small ubiquitin-related modifier 2, anticorps SUMO2, anticorps LOC711990, anticorps LOC714892

Sujet: SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.

Poids moléculaire: 10,871 Da with 95 AA, 11,637 Da with 103 AA

UniProt: P61956, P55854