RGS18 anticorps

N° du produit ABIN2462635

Détail du produit anti-RGS18 anticorps

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS18 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RGS18.

Information d'application

Indications d'application: RGS18 antibody can be used for detection of RGS18 by ELISA at 1:62500. RGS18 antibody can be used for detection of RGS18 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store RGS18 antibody at -20 °C.

Détails sur RGS18

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Autre désignation: RGS18 (RGS18 Produits)

Synonymes: anticorps RGS18, anticorps rgs18, anticorps RGS13, anticorps regulator of G-protein signaling 18, anticorps regulator of G protein signaling 18, anticorps RGS18, anticorps rgs18, anticorps LOC100224724, anticorps Rgs18

Sujet: RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Poids moléculaire: 26 kDa

ID gène: 64407

NCBI Accession: NP_570138

UniProt: Q9NS28

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling