EGLN3 anticorps
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- Antigène Voir toutes EGLN3 Anticorps
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EGLN3 est non-conjugé
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Application
- ELISA, Western Blotting (WB)
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EGLN3.
- Top Product
- Discover our top product EGLN3 Anticorps primaire
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- Indications d'application
- EGLN3 antibody can be used for detection of EGLN3 by ELISA at 1:1562500. EGLN3 antibody can be used for detection of EGLN3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store EGLN3 antibody at -20 °C.
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- Antigène
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Autre désignation
- EGLN3 (EGLN3 Produits)
- Synonymes
- anticorps zgc:77019, anticorps wu:fj78a08, anticorps EGLN3, anticorps phd3, anticorps PHD-3, anticorps PHD3, anticorps SM-20, anticorps 2610021G09Rik, anticorps AI505553, anticorps AI648162, anticorps Hif-p4h-3, anticorps Phd3, anticorps HIFP4H3, anticorps HIFPH3, anticorps egl-9 family hypoxia-inducible factor 3, anticorps egl-9 family hypoxia inducible factor 3, anticorps egl-9 family hypoxia-inducible factor 3 L homeolog, anticorps egln3, anticorps EGLN3, anticorps egln3.L, anticorps Egln3
- Sujet
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
- Poids moléculaire
- 27 kDa
- ID gène
- 112399
- NCBI Accession
- NP_071356
- UniProt
- Q9H6Z9
- Pathways
- Positive Regulation of Endopeptidase Activity
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